Zdenek Skrott Selected Research

Ditiocarb (Sodium Diethyldithiocarbamate)

1/2022	Cannabidiol-induced activation of the metallothionein pathway impedes anticancer effects of disulfiram and its metabolite CuET.
1/2020	Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway.
12/2017	Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.
10/2012	Diethyldithiocarbamate complex with copper: the mechanism of action in cancer cells.

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Zdenek Skrott Research Topics

Disease

5	Neoplasms (Cancer) 01/2022 - 10/2012
5	Alcoholism (Alcohol Abuse) 01/2022 - 10/2012
1	Multiple Myeloma 01/2022
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2020
1	Prostatic Neoplasms (Prostate Cancer) 01/2019

Drug/Important Bio-Agent (IBA)

7	Pharmaceutical PreparationsIBA 01/2022 - 10/2012
7	CopperIBA 01/2022 - 10/2012
7	Disulfiram (Antabuse)FDA Link 01/2022 - 10/2012
4	Ditiocarb (Sodium Diethyldithiocarbamate)FDA Link 01/2022 - 10/2012
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 12/2017
2	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2019
1	CannabidiolIBA 01/2022
1	MetallothioneinIBA 01/2022
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2022
1	Bortezomib (Velcade)FDA Link 01/2022
1	Heavy MetalsIBA 01/2022
1	carfilzomibIBA 01/2022
1	Protein AggregatesIBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2020
1	Culture MediaIBA 10/2019
1	sulfoxideIBA 10/2019
1	Aldehyde DehydrogenaseIBA 10/2019
1	Vorinostat FDA Link 01/2019
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2019
1	EnzymesIBA 01/2019
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2019

Therapy/Procedure

2	Therapeutics 01/2022 - 01/2022
1	Drug Therapy (Chemotherapy) 01/2022
1	Castration 01/2019